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Ethics declarations Conflict of interest Sun-Ki Kim, Managing Editor of Food Science and Biotechnology , was not involved in the editorial consideration of this manuscript

Timeline recommendations by previous dose For those coming off low-dose tirzepatide (2.5 to 5mg), a 20 to 25 day washout is generally sufficient

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Compared to the first-generation GLP-1R agonist, tirzepatide has three critical improvements: first, many residues in peptide backbone are changed to obtain GIPR-activating activity