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Therefore, TRZ has a good therapeutic window with minimal toxicity (Min and Bain 2021)
Targeting Ventilatory Instability and High Loop Gain About one-third of patients with OSA have increased ventilatory instability or high loop gain, which is an exaggerated change in ventilatory drive in response to relatively small changes in the partial pressure of carbon dioxide (PaCO 2 ) levels detected by chemoreceptors [12]
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Lovatt1 et al
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