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In December 2025, the administration also introduced the BALANCE (Better Approaches to Lifestyle and Nutrition for Comprehensive hEalth) model, a five year CMS Innovation Center (CMMI) model that intends to expand access to obesity drugs in Medicaid and Medicare by negotiating lower GLP-1 prices with manufacturers

In phase 2 clinical trials, patients were given a low dose (1 mg) of retatrutide initially, and the dosage was increased slowly and gradually to reduce the risk of side effects