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Executive Summary Written by Jonathan Wright, British Clinical Pharmacist Last reviewed: February 2026 Glucagon-like peptide-1 (GLP-1) receptor agonists including semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro) have transformed the treatment of obesity and type 2 diabetes
Medications with narrow therapeutic windows, such as warfarin, digoxin, or certain antiepileptic drugs, may require more frequent monitoring when tirzepatide is initiated, as delayed gastric emptying could affect absorption rates and peak concentration timing
Implication: research supports coaching for weight loss adherence
It typically resolves within a few hours and many patients don't find it bothersome
