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Epimerization at C-3'' in butirosin biosynthesis by an NAD(+) -dependent dehydrogenase [PMID: 25600434] Laboratory literature summary: Epimerization at C-3'' in butirosin biosynthesis by an NAD(+) -dependent dehydrogenase BtrE and an NADPH-dependent reductase BtrF
A distinctive effect from the phase 3 data is dysesthesia, a skin-sensation symptom described as tingling or sensitivity, more common at higher doses
[25] Like GSTP, GSTM1 is involved in regulating apoptotic pathways through direct proteinprotein interactions, although it acts on ASK1, which is upstream of JNK
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