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M., Schwahn, B., Tokatli, A., Dursun, A., Coskun, T., Chalmers, R
Synergy between the two pathways The additive effect happens at several levels
SS-31 (elamipretide) , a mitochondria-targeted peptide that stabilizes cardiolipin to support energy production, became the first FDA-approved mitochondrial therapeutic in 2025, though only for the rare Barth syndrome, with the brain rationale still mechanistic and no cognitive trials
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