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Patients with leptin resistance tend to experience at least 2 of the following symptoms: Inability to lose weight despite eating a calorie-restricted diet and exercising regularly Constant weight gain is usually accompanied by a ravenous appetite Constant food cravings, even after eating a large meal Constant fatigue, low energy, or feeling sluggish Cold body temperature(defined as less than 98.0 degrees F) Low resting heart rate(defined as 50-60 first thing in the morning assuming that you are both overweight and not aerobically conditioned) Worsening symptoms of hypothyroidism (Hypothyroidism frequently accompanies leptin resistance) These are what I call the warning signs of Leptin resistance
doi: 10.1016/S0140-6736(08)61689-X 156
Eat smaller, more frequent meals throughout the day to manage stomach upset from GLP-1s
References Graaf, C
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