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Houstis, N., Rosen, E.D

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Dysregulated mitochondria-organelle interactions as a central driver of ovarian aging Building on the physiological interactions outlined above, this section represents the central focus of the review and examines how progressive disruption of mitochondria-centered organelle networks constitutes a unifying pathological mechanism underlying ovarian aging

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The PCCA gene is located on chromosome 13q32.3 and is composed of 32 exons that generate eleven alternatively spliced mRNAs, each of which encode a unique protein isoform

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