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Common side effects and their frequency Clinical trial data from the STEP program provides precise frequency data: Two mechanisms drive the nausea
This mechanism reduces food intake and hunger signaling independent of their blood sugar-lowering effects, making them effective for weight management in non-diabetic populations
It is noteworthy that the study populations were highly specific in these trials (refer to inclusion and exclusion criteria sections of Table 1) and most trials recruited patients with established cardiovascular disease or having high risk of cardiovascular disease
Early signals from metabolic improvements (blood pressure, lipids, inflammation markers) are encouraging, but until a dedicated outcomes trial confirms cardiovascular benefit, this remains an unanswered question
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