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Particularly for heart failure, several clinical trials and meta-analyses have already confirmed that SGLT2is reduce HHF by approximately 30% in both HFrEF and HFpEF, with or without diabetes [46]
Unlike some other diabetes medications, such as sulphonylureas or insulin, GLP-1 receptor agonists generally do not cause hypoglycaemia when used alone
In some cases, it can lead to new problems such as paranoia or aggression
So the concern is not irrational
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