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In addition to affecting L-type VSCCs in murine fibroblast L929 cells, BHBA was also reported to modulate N -type calcium channels and Cl channel in cultured neurons ( -dependence of VGLUT2 ( 2+ levels through the G subunit/phospholipase C (PLC)/inositol-1,4,5-trisphosphate (IP3) pathway in monocyte-derived cells ( Our results demonstrated that blocking L-type VSCCs in hippocampal neurons also blocked the effects of BHBA on CaMKII/p-CREB activation, suggesting that the BHBA-induced increase of intracellular Ca 2+ levels and subsequent activation of CaMKII/p-CREB/BDNF are mediated by L-type VSCCs
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