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Haschtmann D, Ferguson SJ, Stoyanov JV

Yes, weight loss with Semaglutide or Tirzepatide can occur even without exercise, although adding movement may improve results

JAMA 322 , 21042114 (2019)

An NNMT Inhibitor Increases Strength and Alleviates the Need for Muscle Recovery To test the effects of 5-amino-1MQ, the Texas-based research group divided aged mice into four groups: one sedentary group with low activity, another sedentary group given the compound, a group that underwent rigorous exercise without treatment, and another that underwent exercise and treatment