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As a glucagon-like peptide-1 (GLP-1) receptor agonist, semaglutide simulates the action of the endogenous hormone GLP-1, which plays a crucial role in glucose metabolism and appetite regulation
It is the most widely studied tissue repair peptide in the preclinical literature
Methylation of either of the nitrogen atoms in the imidazole rings of the histidine residues 6, 13 and 14 prevents formation of bridging histidine moieties
Combination pharmacotherapy, while sometimes used in clinical practice, is generally off-label with limited evidence in post-bariatric populations and requires careful monitoring
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