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If the patient cannot tolerate the 2.4mg dose, then decrease the dose to 1.7mg for 4 weeks
No driving to the clinic, no sitting in a waiting room reading magazines from 2019
Engineered exosomes that are surfacemodified with CD44 antibodies can specifically accumulate within inflamed joints, thereby augmenting the local concentration of methotrexate and substantially mitigating systemic side effects [456]
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