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Data was graphed after normalizing each insulin time course by dividing by the secretion rate at each time point by the rate obtained in the presence of 20 mM glucose prior to the addition of test compounds
In the pancreas, GLP-1 receptors act in a glucose-dependent manner to prompt insulin secretion and inhibit glucagon secretion [8, 12, 13]
Oral semaglutide access through compounding is more limited since the specific absorption enhancer technology and formulation requirements create additional complexity
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