glp 1 2 and 3 GLP-1 Drugs May Lower CV Risk in TAVI Patients With Diabetes or Obesity The GLP-1 weight loss revolution

10.1128/aac.49.6.2276-2282.2005 51 CiofuO.SmithS.LykkesfeldtJ

Post-treatment, the expression of the serotonin reuptake transporter (SERT) significantly increased, while tryptophan hydroxylase-1 (TPH-1) expression significantly decreased in colonic tissue, suggesting exendin-4 mitigates visceral hypersensitivity by upregulating SERT and downregulating TPH-1

Our findings highlighted the fact that endogenous baseline GLP-1 concentration has significant influence on insulin secretory and glucose-lowering responses to a larger extent than previously thought

however, close monitoring for gastrointestinal adverse events is warranted in cirrhotic patients, who may have reduced tolerance