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The endpoint algorithms were validated and showed a sensitivity of over 99% for mortality in the National Death Index, a positive predictive value of 94% for myocardial infarction, 95% for stroke and 98% for heart failure hospitalization 33,35,36,37,38,39,40

Common adverse effects include dry skin, chapped lips, dry and irritated eyes, nosebleeds, sun-sensitive skin, worsening acne, and, in serious cases, mood disorders (eg, depression, anxiety) and birth defects or other risks to a fetus

The requirements for filing a claim vary according to the state of residence

Design, synthesis and biological evaluation of novel pyrimidinedione derivatives as DPP-4 inhibitors