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The Sulfur transfer pathway plays a role in the maintenance of redox homeostasis and oxidative stress, mainly due to the upregulation of intracellular Cys, GSH, and GSSG and the inhibition of ROS as a result of Cys-tRNA synthetase (CARS) deficiency (Floros et al., 2022
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As an essential component of glutathione peroxidase, it also helps carry out important enzyme processes that protect lipids (fats) in cell membranes
Seiler A, Schneider M, Forster H, Roth S, Wirth EK, Culmsee C, Plesnila N, Kremmer E, Radmark O, Wurst W, et al: Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death
