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When a road (or a tendon) gets broken, you need a construction crew to fix it

10.1016/j.jpsychires.2006.07.013 J Psychiatr Res

Without identification and characterization of these metabolites, it is not possible to assess their pharmacological activity, inactivity, or possible toxicities as well as potentially identify which enzymes are responsible for their clearance, which is necessary to predict possible drug-drug interactions