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According to the Wegovy SmPC, hypersensitivity reactions including urticaria can occur, though the frequency is classified as uncommon (affecting between 1 in 100 and 1 in 1,000 patients)
This corresponds to an absolute rate of 1.04 cases per 1000 individuals in the tirzepatide group and 2.02 per 1000 in the control group, yielding an absolute risk reduction (ARR) of 0.98 per 1000 (NNT=1020)
The rate of weight loss with semaglutide varies by dose, duration, and individual factors, and may be more rapid in the early weeks of treatment
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