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10.1042/BJ20061194 Biochem
The dose starts at 0.25 mg and increases every 4 weeks until reaching a maintenance dose, usually 2.4 mg
The peptide's structure contains the 4-10 melanocortin receptor binding region common to -MSH and adrenocorticotropin (ACTH), but incorporates a lactam bridge between amino acids 4 and 10, along with specific amino acid substitutions (Nle4, Asp5, D-Phe7, Lys10) that enhance receptor binding affinity and metabolic stability
For many individuals, it becomes the first medication that allows them to feel in command of their appetite rather than reacting to constant hunger cues
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