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In methionine-choline deficient (MCD) diet-induced NAFLD mice, L-carnitine upregulated hepatic PPAR protein expression while inhibiting NF-B p65 activation, thereby attenuating liver inflammation and fibrosis (47)

These complexes then translocate into the nucleus, where they drive the transcription of pro-fibrotic genes while suppressing epithelial gene expression, thereby initiating EMT and subsequent fibrosis (183)

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Diseases which can cause or induce secondary diabetes include Cushings disease, pancreatitis, cystic fibrosis, certain neoplasms, and more