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Adipocyte NADH dehydrogenase reverses circadian and diet-induced metabolic syndrome

Last updated June 3, 2026 Editorial policy A Weight-Loss Drug With an Unexpected Benefit If youve been anywhere near the news in the past two years, youve heard of GLP-1 receptor agonists drugs like Ozempic, Wegovy, and Mounjaro that have transformed weight loss and diabetes management

Adding the second receptor improved weight loss from roughly 15% to 22.5% in clinical trials (Jastreboff et al., NEJM 2022)

7-9 GLP-1 signaling has been shown to promote microglia-mediated expression of neurotrophic factors, such as brain-derived neurotrophic factor and nerve growth factor, to promote neuronal survival and inhibit stress pathways in neurodegenerative conditions