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Minor changes, such as switching out inert ingredients like fillers, wont cut it, but adding an ingredient that plays a therapeutic role might, Feldman said

Severe headaches, vision changes, or new neurologic symptoms should not wait for routine labs

For antigen delivery, a modified vaccinia Ankara (MVA) virus and adjuvanted protein subunit approach in a heterologous prime-boost regimen were selected, as this has been proposed to elicit stronger, broader and/or longer-lasting immunity than homologous vaccinations 29

For people with MS who may already experience neurogenic bowel dysfunction, these additional gastrointestinal disturbances could significantly impact daily functioning and quality of life