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1,2 In a 2005 Cochrane review, patients who received high dosages of oral vitamin B 12 (1 to 2 mg daily) for 90 to 120 days had an improvement in serum vitamin B 12 similar to patients who received intramuscular injections of vitamin B 12

Hydroxocobalamin: Adverse reactions (IV use)

High Caco-2 permeability is a favorable sign for oral absorption

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