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Reported side effects in studies include: nausea diarrhea constipation vomiting abdominal discomfort These effects were generally dose-dependent and more common during the early stages of treatment
Levothyroxine (or other thyroid hormone replacement) remains necessary
RC-fed Dpp4 / mice exhibited no detectable plasma DPP4 activity, an approximately 8-fold increase in plasma active GLP-1, reduced fasting glucose, improved glucose tolerance, and no difference in body weight compared with Dpp4 +/+ mice (Figure 2A and Supplemental Figure 1, A and B
Beyond digestive effects, some patients ask about hair shedding and facial volume changes during rapid weight loss, which are tied to the speed of weight loss rather than the drug directly
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