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Abbreviations AAV: Adeno-associated viruses AuNPs: Gold nanoparticles BMPO: 5-tert-butoxycarbonyl-5-methyl-1-pyrroline N-oxide CAT: Catalase CDFI: Color doppler flow imaging CH: Congenital hydronephrosis CTPO: 5-Carboxy-2,2,5,5-tetramethyl-1-pyrrolidinyloxy DEGs: Differentially expressed genes DEPs: Differentially expressed proteins DLS: Dynamic light scattering DMEM: Dulbeccos modified eagle medium DMPO: 5,5-Dimethyl-1-pyrroline N-oxide DTT: Dithiothreitol ESR: Electron spin resonance FBS: Fetal bovine serum FDR: False discovery rate GAPDH: Glyceraldehyde 3-phosphate dehydrogenase GEO: Gene expression omnibus GSH-Px: Glutathione peroxidase H&E: Hematoxylin and eosin HD: Hydrodynamic diameter HK-2: Human kidney-2 HRP: Horseradish peroxidase IACUC: Institutional animal care and use committee ICP-MS: Inductively coupled plasma mass spectrometry IHC: Immunohistochemistry KEGG: Kyoto encyclopedia of genes and genomes LASSO: Least absolute shrinkage and selection operator LC-MS/MS: Liquid chromatography-tandem mass spectrometry MDA: Malondialdehyde MF-NZ: Multifunctional nanozyme OS: Oxidative stress PBS: Phosphate-buffered saline PFA: Paraformaldehyde PMIZ-AuNPs: pH-responsive PEG-SH and imidazole-modified gold nanoparticles POBN: -(4-Pyridyl 1-oxide)-N-tert-butylnitrone PPI: Protein-protein interaction RCT: Renal cortical thickness RF: Renal fibrosis RIF: Renal interstitial fibrosis RI: Resistance index ROS: Reactive oxygen species RT-qPCR: Reverse transcription quantitative polymerase chain reaction SOD: Superoxide dismutase TEM: Transmission electron microscopy TGF-: Transforming growth factor beta TKPTS: Mouse and human proximal kidney tubular cells UCA: Ultrasound contrast agent UUO: Unilateral ureteral obstruction WB: Western blot -SMA: Alpha-smooth muscle actin OH: Hydroxyl radicals References Rai A, Hsieh A, Smith A

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