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While theres no hard evidence that this reduction in temperature is due to the effects of GLP-1 treatment on the hypothalamus, its thought that activating these receptors in the hypothalamus could lower your body temperature, meaning you feel colder

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As Dermatologist Katherine Armour, a Melbourne-based skin expert, says, "There is often a change in the appearance of many of their moles, such that it can be difficult to detect melanomas or sometimes, clinically, for us to exclude melanoma." Melanotan is classified as an unapproved product by Australias Therapeutic Goods Administration (TGA)

The Journal of Physiology , 589(Pt 4), 963-973