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In addition, their improved blood pressure, cholesterol, blood sugar levels reverted back to their pre-trial levels, highlighting the potential drawbacks associated with GLP-1 agonists in the long-run
As all people with diabetes are at high risk of CVD, HF and CKD over time, real-world evidence and cost-effectiveness studies of GLP-1 RA and SGLT2i in broad populations would help to better target interventions to have the greatest impact on outcomes
Some people respond better to semaglutide
Option 3: Switching to Tirzepatide Another option for patients who are not achieving their weight loss goals on certain GLP-1s, like Semaglutide, is switching to Tirzepatide, a newer dual-action GLP-1 and GIP receptor agonist that has shown more impressive weight loss results in recent clinical trials
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