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however, human safety profiles remain undefined

Glutathione is given intravenously because this route delivers the antioxidant directly into the bloodstream, bypassing digestive breakdown that destroys nearly all of an oral dose

RONS then oxidize proteins, lipids, nucleic acids, and endothelial junctional complexes while depleting endogenous antioxidant reserves [6, 7]

However, the isolation of antioxidant enzymes in their native form is a very cumbersome and cost-intensive approach, apart from other limitations such as potential immunological problems which can arise during their systemic application as therapeutic agents [69]