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Moreover, IONP-LPrA2 reduced PC tumorspheres (treated with 5-FU) via notch signaling and suggesting that leptin might be involved in reducing the cytotoxic effect of chemotherapeutic drug and facilitating chemoresistance [71]
Dato-DXd is also being evaluated as first-line therapy for patients with advanced/metastatic NSCLC with PD-L1 expression 50% in the phase III TROPION-Lung08 trial comparing Dato-DXd in combination with pembrolizumab vs
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