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determined that melatonin decreased LPO levels and increased GSH levels in hepatorenal oxidative damage induced by MTX (Reference Jahovic, Cevik and Sehirli38)
Conditions: a) HOAc or HClO 4 , MeOH/DCM (2:3), rt, 3 d
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[7] That preclinical promise carried the compound into a human Phase II program for postoperative ileus but the randomized, placebo-controlled trial in bowel-resection patients did not meet its primary efficacy endpoint, and clinical development was subsequently discontinued
