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Counterpoint #1 The observation that people with heart disease are more likely to have higher TMAO levels does not mean that TMAO causes heart attacks (and the authors do not claim that it does)

Research suggests that continued metformin use and structured exercise programs can help reduce weight regain

doi: 10.3389/fendo.2022.857930 8

Given the complex and heterogeneous trajectory of FFM during weight regain and considering that FFM is a broader, less metabolically strategic compartment than specific lean mass, as previously discussed, evaluating the qualitative deterioration of muscle tissue emerges as a more critical objective