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doi: 10.3389/fphar.2021.632295 Received 07 December 2020 Accepted 13 April 2021 Published 10 June 2021 Volume 12 - 2021 Edited by Chiara Bianca Maria Platania, University of Catania, Italy Reviewed by Doreen Schmidl, Medical University of Vienna, Austria Francesca Lazzara, University of Catania, Italy Updates Copyright 2021 Zlatar, Kokot, Vuletic, Masnec, Kralj, Perisa, Barisic, Radic, Milanovic, Drmic, Seiwerth and Sikiric

Conclusion The distinction of bacteriostatic water and reconstitution solution such as water for injection (WFI) matters

Proper storage and handling will help maintain methylcobalamins effectiveness throughout your treatment course

Necroptosis and pyroptosis are characterized by the formation of plasma membrane pores via caspase-1, which leads to the pro-inflammatory cytokines release and cell lysis, and thus controls the inflammatory response