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Adverse effects have been rare and generally mild, encompassing transient fatigue and occasional redness at injection sites

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Melatonin biosynthesis in plants: multiple pathways catalyze tryptophan to melatonin [PMID: 27600803] Laboratory literature summary: Melatonin biosynthesis in plants: multiple pathways catalyze tryptophan to melatonin in the cytoplasm or chloroplasts