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However, avoid excessive polypharmacy, 2-3 peptides maximum for musculoskeletal applications
Combination pharmacotherapies may achieve greater bodyweight loss than monotherapies, via additive or synergistic effects, when the individual agents target different pathways [12]
NICE has not yet issued guidance on either agent, as appraisal processes are typically initiated only after regulatory approval, although scoping can occur earlier
[This] limits its ability to prove causation and may introduce biases from unadjusted confounders like lifestyle differences and other unknown factors, says Dr
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