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269 In EGFR-mutant NSCLC, AXL activation by GAS6 stabilizes the E3 ligase RAD18 via ubiquitin-like modification, promoting monoubiquitination of PCNA and facilitating error-prone translesion DNA synthesis, thus accelerating mutagenesis and resistance

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Authors : Yi Wen, Deven Lemen, Yanzhu Lin, Yan Q Chen, Ajit Regmi, William C Roell, Melissa K Thomas, Mark L Hartman, Tamer Coskun, Zvonko Milicevic, Axel Haupt, Giacomo Ruotolo, Robert J Konrad Source : This study investigated the effect of Retatrutide on circulating concentrations of the angiopoietin-like protein 3/8 complex (ANGPTL3/8) and its relationship with serum lipid levels