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Theres still a lot we dont know about these medications, and lots of research is underway
In MASH, people have found glucagon resistance: the body produces glucagon but somehow it doesnt act on the liver. That impaired signaling, she said, appears to be one reason patients with MASLD accumulate fat within organs
Su M-H, Shih Y-H, Lin Y-F, Chen P-C, Chen C-Y, Hsiao P-C, et al
Bottom line While feeling cold is not an official side effect of semaglutide, it can happen to some people as their bodies adjust to a lower caloric intake and weight loss on the medication
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