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As with CYP2E1, there are substantial inter-ethnic differences in CYP2D6 across populations, ranging from complete loss of function or reduction in functional activity (2570% of the population, dependent on ethnic origin and geographical location) to extensive, ultra-rapid metabolisers (1.59.3% of the population) (see Table 3 in the supplementary data for a summary of the evidence) [17, 38]

doi:10.15252/embr.202256574 11

Pharmaceutics 13 (12), 2041

For example, your doctor might ask you to keep taking vitamin D or calcium if youre having thyroid or parathyroid surgery, or an iron supplement if you have iron deficiency anemia