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Preclinical in vivo models have examined its effects on nitric oxide synthase activity, extracellular matrix protein expression, and actin cytoskeletal dynamics in connective tissue contexts
Subsequently, phosphorylated Smad3 bound to Smad4 (the partner Smad) and was transported from the cytoplasm to the nucleus to activate the transcription of downstream target genes related to ANP and -MHC (96)
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