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For biologics, where the interchangeability barrier and PBM rebate dynamics slow substitution, the erosion is more prolonged but the trajectory is identical

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Changes in Health Conditions: Treatment suitability may need to be reviewed if new medical concerns develop or planned procedures affect ongoing use

In addition, the possibility to manipulate SLC25A39 and/or to regulate the amount of GSH that enters mitochondria also offers the opportunity to study the importance of mitochondrial GSH in more detail, especially in mitochondria-rich tissues like liver or kidney