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Preclinical studies using T4 (including the RGN-259 ophthalmic clinical trials) have not identified significant adverse events at therapeutic doses
Aged fibroblasts in culture, for example display a threefold reduction in population doubling time [34], with older cells reported to have an increased G0/G1 phase proportion due to repression of cell cycle progression genes [35]
Triple, quadruple and quintuple agonists are now in development, as is an expanded range of oral formulations
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