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Weight loss of 10% or more may necessitate levothyroxine dose adjustments, and patients should be educated to recognise symptoms of both hypothyroidism (fatigue, cold intolerance, constipation) and hyperthyroidism (palpitations, anxiety, tremor) that might indicate the need for dose modification
However, if symptoms persist beyond 48 hours, worsen, or show signs of infection (increasing redness, warmth, pus, or fever), contact your GP or diabetes care team promptly
We observed no evidence of dominance effects ( P = 0.80), indicating that the allelic dosage of the T allele contributes to efficacy in an additive manner
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