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1315 population doublings as per previous Gecko v1 screens), MAGeCK RRA overrepresentation analysis of genes enhanced in 5FU groups at endpoint showed that OxPhos genes were highly enriched (Fig

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This special interplay further highlights that the loss of any one system can overwhelm the compensatory capacity of the others, forcing the CNS into a state of redox imbalance, glial activation, and progressive inflammation (Figure 1)