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Methods: A comprehensive search was conducted across PubMed, Scopus, and Embase up to July 2024
Conclusion Both the central circadian clock system and the control center of the GH/IGF-1 axis are located in the hypothalamus and related genes/hormones are expressed/released in circadian rhythm, which regulate metabolism through multi-level interactions
Despite steady mechanistic innovation across immunotherapeutic modalities, clinical translation ultimately hinges on solving the complex biology of GBM, and several bottlenecks persist
The documented concern categories include: claims implying compounded GLP-1 products are equivalent to FDA-approved drugs
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