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However, current related interventions remain at the preclinical stage, and caution must be exercised regarding their network effects due to crosstalk with apoptosis, pyroptosis, and other PCD modesexcessive inhibition of necroptosis may lead to a shift of death pathways towards pyroptosis or other lytic PCDs, resulting in unexpected immunological consequences (81, 82)
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These findings have implications for stroke rehabilitation research, traumatic brain injury recovery, and potentially neurodegenerative disease treatment approaches
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