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There is no single best one, because each targets a different pathway

References Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, et al

The reaction product, N-Hcy-Lys, was purified by HPLC using a reverse phase X Bridge Prep C18 preparative column (19 100 mm, 5 m) from Waters (Milford, MA, USA)