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Similarly, in male mice, a biogenic immune stressor producing sustained IFN- elevations induced chronic increases in both peripheral and brain IDO activity, accompanied by widespread TRP depletion, indicating that prolonged cytokine signalling drives central and peripheral TRP loss [68]

Neurotransmitter synthesis A neurotransmitter is a chemical released from a nerve cell that transmits an impulse to another nerve cell or an effector cell, such as a muscle cell