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Clinical data shows semaglutide produces approximately 15-17% body weight reduction at maximum doses over similar timeframes
"Constipation from GLP-1s can be compounded by the fact that people are eating less," says Hamilton, "resulting often in less fiber consumption and less stool bulk overall." Many people also drink less fluid to avoid feeling overly full on GLP-1 medications, which can also lead to constipation
The most notorious innovation of this era was the rainbow pillcapsules combining amphetamines, thyroid hormone, diuretics, and laxatives
