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Semaglutide showed the greatest effect with 6.14-kg weight loss (an expected effect, given the pharmacological profile, including a longer half-life and stronger receptor activity, of this newer agent) followed by liraglutide at 4.83 kg and exenatide at 3.91 kg
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Next, the mitochondrial fuel dependency tests were performed in the vector and the SIRT3OE adipocytes, achieved by co-treatment of inhibitors of mitochondrial pyruvate carrier (glucose oxidation pathway), glutaminase (glutamine oxidation pathway) and CPT1 (FAO pathway) successively
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